Tenapanor Agreement

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The Tenapanor Agreement: What You Need to Know

In the world of pharmaceuticals, deals between companies are commonplace. One such agreement caught the attention of many industry insiders recently – the Tenapanor agreement. In this article, we will dive into what this agreement is all about and what it means for the companies and their stakeholders.

Understanding Tenapanor

Tenapanor is a drug that is used to treat gastrointestinal disorders. It is marketed under the brand name Ibsrela and was developed by Ardelyx. The drug works by blocking the NHE3 protein in the intestines, which reduces the absorption of sodium and water. This results in softer stools and less pain associated with bowel movements.

The Tenapanor Agreement

In September 2021, it was announced that AstraZeneca had entered into an agreement with Ardelyx to purchase the exclusive global rights to Tenapanor. Under the terms of the agreement, AstraZeneca will pay Ardelyx $35 million upfront and up to $185 million in additional payments based on certain regulatory and commercial milestones. In return, AstraZeneca will have the right to develop and commercialize Tenapanor for all indications.

What This Means for Ardelyx

For Ardelyx, the Tenapanor agreement is a win. The company will receive upfront and milestone payments that will help it continue to fund its operations. In addition, by partnering with a larger pharmaceutical company like AstraZeneca, Ardelyx gains access to additional resources and expertise to help further develop Tenapanor and bring it to market.

What This Means for AstraZeneca

For AstraZeneca, the acquisition of the exclusive global rights to Tenapanor allows the company to expand its gastrointestinal portfolio. The drug is a promising treatment for irritable bowel syndrome with constipation (IBS-C) and is expected to generate significant revenue for the company.

What This Means for Patients

The Tenapanor agreement is ultimately good news for patients suffering from gastrointestinal disorders. With the acquisition of the exclusive global rights to Tenapanor, AstraZeneca will be able to bring the drug to market faster and more efficiently. This means that patients will have access to a promising new treatment option for their condition.


The Tenapanor agreement between AstraZeneca and Ardelyx is an exciting development in the world of pharmaceuticals. With this deal, Ardelyx gains the resources and expertise it needs to bring Tenapanor to market, while AstraZeneca expands its gastrointestinal portfolio. Ultimately, this is good news for patients suffering from gastrointestinal disorders who will now have access to a promising new treatment option.